Gabapentin enacarbil
Horizant (gabapentin enacarbil) is a small molecule pharmaceutical. Gabapentin enacarbil was first approved as Horizant on 2011-04-06. It is used to treat bipolar disorder, epilepsy, partial epilepsies, phobic disorders, and postherpetic neuralgia in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Horizant
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| horizant | New Drug Application | 2025-04-28 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
576 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 8 | 7 | 16 | 36 | 22 | 83 |
| Pain | D010146 | EFO_0003843 | R52 | 3 | 12 | 13 | 20 | 22 | 65 |
| Neuralgia | D009437 | EFO_0009430 | — | 2 | 12 | 7 | 10 | 12 | 42 |
| Restless legs syndrome | D012148 | EFO_0004270 | G25.81 | 4 | 4 | 7 | 8 | 3 | 26 |
| Chronic pain | D059350 | — | — | 1 | 7 | 4 | 3 | 10 | 24 |
| Healthy volunteers/patients | — | — | — | 11 | — | 1 | 1 | 9 | 22 |
| Agnosia | D000377 | EFO_0007136 | F88 | 1 | 3 | 4 | 10 | 3 | 20 |
| Postherpetic neuralgia | D051474 | — | — | — | 6 | 5 | 3 | 7 | 20 |
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | 8 | 4 | 8 | 1 | 18 |
| Syndrome | D013577 | — | — | — | 3 | 7 | 4 | 3 | 17 |
Show 146 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 1 | 2 | — | 8 | 10 |
| Depression | D003863 | — | F33.9 | — | 2 | 2 | — | 4 | 8 |
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | 1 | 1 | — | 4 | 5 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | — | 3 | — | 1 | 4 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | 1 | — | 3 | 4 |
| Alcohol drinking | D000428 | EFO_0004329 | — | — | 3 | 1 | — | — | 4 |
| Anterior cruciate ligament injuries | D000070598 | — | — | — | 2 | 3 | — | — | 3 |
| Emergence delirium | D000071257 | — | — | — | — | 2 | — | 1 | 3 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | — | 1 | 1 | — | 1 | 3 |
| Tinnitus | D014012 | — | H93.1 | — | 3 | 1 | — | — | 3 |
Show 53 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | 2 | 3 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | 3 | — | — | — | 3 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | — | 2 | 3 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | 1 | 1 | — | — | 2 | 3 |
| Psychotic disorders | D011618 | — | F20.81 | 1 | 3 | — | — | — | 3 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | — | 3 | — | — | — | 3 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 3 | — | — | — | 3 |
| Hiv | D006678 | — | O98.7 | — | 1 | — | — | 2 | 3 |
| Male breast neoplasms | D018567 | — | — | — | 1 | — | — | 1 | 2 |
| Central nervous system neoplasms | D016543 | — | — | 1 | 2 | — | — | — | 2 |
Show 38 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | 2 | 3 |
| Burns | D002056 | — | T30.0 | 1 | — | — | — | 1 | 2 |
| Refractive errors | D012030 | HP_0000483 | H52.7 | 1 | — | — | — | — | 1 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | 1 | — | — | — | — | 1 |
| Spondylosis | D055009 | — | M47 | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Weight loss | D015431 | — | — | 1 | — | — | — | — | 1 |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | 1 | — | — | — | — | 1 |
| Pervasive child development disorders | D002659 | EFO_0003756 | F84 | 1 | — | — | — | — | 1 |
| Alopecia areata | D000506 | EFO_0004192 | L63 | 1 | — | — | — | — | 1 |
Show 9 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 3 | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 3 | 3 |
| Sciatica | D012585 | — | M54.3 | — | — | — | — | 3 | 3 |
| Cardiac surgical procedures | D006348 | — | — | — | — | — | — | 2 | 2 |
| Hysterectomy | D007044 | EFO_0003881 | — | — | — | — | — | 2 | 2 |
| Motor activity | D009043 | EFO_0003940 | — | — | — | — | — | 2 | 2 |
| Post-dural puncture headache | D051299 | — | — | — | — | — | — | 2 | 2 |
| Herpes simplex | D006561 | — | B00 | — | — | — | — | 2 | 2 |
| Vulvodynia | D056650 | — | N94.81 | — | — | — | — | 2 | 2 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | — | — | — | — | 2 | 2 |
Show 91 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Gabapentin enacarbil |
| INN | gabapentin enacarbil |
| Description | Gabapentin enacarbil is a carbamate ester that is the N-[1-(isobutyryloxy)ethoxy]carbonyl derivative of [1-(aminomethyl)cyclohexyl]acetic acid. The prodrug for gabapentin, used for treatment of neuropathic pain and restless legs syndrome. It has a role as a prodrug, an anticonvulsant and a calcium channel blocker. It is a monocarboxylic acid, a carbamate ester, a carboxylic ester and an acetal. It is functionally related to a gamma-aminobutyric acid and a gabapentin. |
| Classification | Small molecule |
| Drug class | gabamimetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(OC(=O)NCC1(CC(=O)O)CCCCC1)OC(=O)C(C)C |
Identifiers
| PDB | — |
| CAS-ID | 478296-72-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1628502 |
| ChEBI ID | 68840 |
| PubChem CID | 9883933 |
| DrugBank | — |
| UNII ID | 75OCL1SPBQ (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 548 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
2,076 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use